Baby: Welcome to my Mommy’s podcast.
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Katie: Whats up and welcome to “The Wellness Mama Podcast.” I’m Katie from wellnessmama.com and wellnesse.com, that’s wellness with an E on the top. And I’m right here at this time with my pal, Naveen, who’s an intensely curious entrepreneur who has been taking up some massive, audacious concepts to push humanity ahead. He’s the writer of the award-winning guide “Moonshots: Making a World of Abundance,” and his present moonshot adventures are Viome and Moon Specific, which is an area firm. However as a serial entrepreneur, he’s additionally based InfoSpace, Intelius, and Expertise Smart, amongst others.
And his present work is in Viome Life Sciences, which was based in 2016 with a mission of constructing sickness optionally available by predicting and stopping persistent illness by a deeper understanding of a person’s biology at a molecular stage. And it’s constructed on an AI-driven platform that analyzes the interplay between meals, our microbiome, and our human selves to develop precision suggestions to forestall and reverse persistent illness. He’s additionally the vice-chairman of the board at Singularity College, and on the board of XPRIZE Basis. He’s been the recipient of many issues together with Entrepreneur of the Yr, Most Artistic Particular person by Quick Firm, High 20 Entrepreneurs, and plenty of extra.
On this episode, we discuss in regards to the human ecosystem and customized optimization of your intestine well being and your total well being. We discuss in regards to the purpose the intestine impacts the complete physique. Why it’s not simply genetics from our dad and mom however really our ecosystem inside our intestine that controls our physique. Why 70% of the immune system is within the intestine. How microbiome stability begins at delivery and even earlier than. How 90% of serotonin is produced within the intestine, not the mind. What makes up the ecosystem of the intestine. We get fairly granular on this one.
The distinction between DNA and gene expression. How some meals may be good for some folks and never others, and how one can know which is greatest for you, but in addition, the universally dangerous meals. Why there are some universality unhealthy ones however not universally good ones. Why he doesn’t suggest harsh merchandise that kill micro organism within the mouth or within the intestine. The true purpose it’s necessary to chew your meals very well earlier than swallowing, and a lot extra. Lot’s of sensible data on this episode. Additionally, numerous hyperlinks to study extra within the present notes at wellnessmama.fm, so test these out. However with out additional ado, let’s be a part of Naveen Jain. Naveen, welcome again.
Naveen: Properly, Katie, so good to see you lastly after a protracted, very long time.
Katie: I’m so excited we get to have a dialog and get to report it and share it at this time, and we’re gonna discuss loads about intestine well being and even past intestine well being, how this impacts the well being of the entire physique. Earlier than we do, although, I might say you’re the one particular person I do know in actual life who has a Moon rock assortment. And so, I might love so that you can simply discuss this as a result of I believe you’re my solely hobbyist Moon rock collector.
Naveen: Properly, I believe, Katie, you recognize, to me, the Moon is symbolic. It’s symbolic of what humanity is able to doing. So, to me, going to the Moon is a method of expressing that there’s nothing that’s unattainable for us to do. Although it’s referred to as “Moonshots” that folks thought was troublesome, if not unattainable to do and having, you recognize, now to have the ability to go to the Moon and to me, the gathering of house rocks really was simply merely a passion of capable of maintain one thing in your hand. That could be even earlier than the delivery of our planet. And it offers you some concept of how fragile we’re that if we don’t handle ourselves, our planet, we as humanity might not survive. As a species, we might not survive.
So, you recognize, concept of when somebody says, “I’m actually frightened about our planet,” ask the planet and planet will inform you, “Don’t you are concerned about me as a result of we…” Planet will just do high quality however human species might not survive. Similar to dinosaurs. And to me, having a Moon rock merely jogs my memory that all of us are related collectively. When one thing outdoors us goes improper, we as inside ecosystem can even be impacted, proper. And that’s coming all the way down to, you recognize, for those who take a look at what’s above, so under is basically what’s outdoors the ecosystem and the universe impacts us, and our ecosystem inside us impacts the universe.
Katie: I really like that you just stated it like that as a result of I interviewed my oldest son on this podcast a pair hundred episodes in the past when he launched a cookbook and you recognize him as nicely. And I requested him that query. , your technology’s gonna face loads within the environmental and local weather stuff. And, I raised this query and he goes, “Properly, mother, you’re really asking the improper query as a result of the…”
Naveen: Oh, I like it, I like it.
Katie: He stated, “The planet is a self-correcting organism. It’s gonna heal itself. It’s only a query of whether or not we get to remain right here when it does. And we have to be asking how we may be extra synergistic inside an atmosphere that’s greater than us.”
Naveen: That’s the excellent reply. That’s precisely how I might see it that…you recognize, when folks say, “Aren’t you frightened in regards to the planet?” I say, “That’s not the query you ought to be asking.” It’s, “Are we frightened in regards to the human species?” That’s what we ought to be asking.
Katie: Which is an ideal segue as a result of that’s one thing that you’re intimately concerned with and I might say not frightened about however working to unravel. My listeners are fairly well being savvy and perceive or at the least have a passing understanding that intestine well being impacts the entire whole physique. However I really feel like this idea is…nicely, we’ve recognized facets of it for a very long time. We’re seeing a lot extra analysis about it proper now. And we’re…due to firms like Viome, we’ve got many extra tangible instruments to really perceive and begin to do one thing about that. However to begin broad, sort of give us an summary of what we imply by the well being of the intestine impacts the well being of the entire physique.
Naveen: So, nicely, to start with, you recognize, let’s simply begin from the start. We as human beings usually are not merely a product of the DNA from our mother and pa. What we’re is a symbiotic ecosystem, and in that ecosystem, 99% of all of the genes which can be really expressed in our human physique usually are not our personal. They arrive from these microbes which can be in our mouth, in our intestine, throughout us. So, think about…I imply, there’s actually…if we take a look at the human beings as such when it comes to all of the genes which can be expressed that makes us who we’re, they aren’t people. They’re largely microbial. We’re dwelling of their world. They don’t reside in our world, proper.
So, after we perceive that, you recognize, despite the fact that you may argue that they’re the puppet masters and we’re merely the host or puppet for his or her profit, and you may argue sometime that perhaps they really created us to unfold them round, perhaps they created us to allow them to rule the world, proper, however in all honesty, we coevolved collectively. In coevolution what occurs is we feed them and we give them a pleasant and heat and comfy place to remain. In flip, they feed us the vitamins that our physique wants to really be wholesome, proper. So, think about from the time a child is born, and I believe that is one thing that most individuals don’t notice, that within the first couple of days of mom’s breast milk is stuffed with oligosaccharides. And that can’t be digested by the human physique. That’s there just for the microbes within the intestine to have the ability to convert into vitamins. Which means it’s to create the ecosystem inside us.
Now think about what nature is telling us, that we simply created a offspring and one of the simplest ways to maintain this offspring wholesome is to not feed it however to feed them who’re going to maintain the offspring wholesome. And because the child goes by the delivery canal, that is the primary publicity the child will get to the entire world of microbiome. It will get…utterly inhales the microbiome because the child’s going by delivery canal. And sadly, among the moms for apparent causes find yourself getting a C-section. They really…the infants usually are not going by the identical…they’re uncovered to pores and skin microbiome moderately by the delivery canal, the microbiome that they’d get by the delivery canal. And that could be a essentially…the child, when it’s born, is definitely…the character has created in a method that the microbes get launched into the child on the time of the delivery and that really now turns into a coevolution course of. And the mom’s breast milk begins to feed these microbes to create this ecosystem.
And because the intestine microbiome begins to get wholesome, it begins to coach our immune system. And I believe that is the elemental half that folks want to grasp. Seventy % of our immune system is alongside our intestine lining. In reality, all of the analysis exhibits that how intestine microbiome is continually coaching our immune system what’s a pal and what’s a foe, proper. So, in some sense, for those who take a look at the human physique, there’s a tube that goes by us. There’s a prime of the tube in your mouth after which there’s the underside of the tube, and you then begin to take a look at all alongside the traces there’s a huge quantity of microbial existence there. They usually in actual fact are continually interacting with our immune system and the immune system is now understanding when there’s really a pathogen that’s coming by the meals or the pathogen that’s coming by the skin world, how one can react to it. And these microbes are the primary sign that tells the immune programs, “This isn’t good. Go do one thing about it, proper.”
And I believe to me, that symbiotic relationship breaks down when there’s a dysbiosis within the intestine. So, I believe as your son identified, not simply the planet however even the human physique is designed to heal itself. The human physique is designed to be in homeostasis. And any time…and whether or not we reduce our pores and skin or whether or not there’s some kind of pathogen or we get some kind of a illness, it usually is designed to heal itself if our physique is in stability. So, when there are intestine microbial actions and the human host are continually in sync and wholesome and our immune system is wholesome, then our physique will really heal itself. When there’s a dysbiosis or imbalance of the intestine microbiome, that is the place the unease occurs. When your physique will not be relaxed, you get illness which we name illness.
Katie: Yeah, so many necessary factors you simply stated to unpack. And I believe the primary being that we actually are extra bacterial than human and also you…right here you stated you might be what you eat nevertheless it goes thus far past that. It’s not even you might be what you eat and even you might be what you eat-eat, however what your intestine micro organism eats and the way it grows. And I really like that you just introduced up the delivery canal factor as a result of I’m a doula and I’ve really helped in a number of C-section births with feeding the child, as a result of such as you stated, for those who don’t…the child is of course meant to seed their intestine by the delivery canal. And if that doesn’t occur, such as you stated, they’re seeding to the hospital room, to pores and skin, to doubtlessly disinfectants which can be in that room, all types of issues. And we all know that this intestine micro organism at delivery, increasingly we study, units you up in your complete life. But in addition, the excellent news is…and I do know that Viome does a variety of analysis on this. All will not be misplaced for those who don’t get an ideal begin. We now have the flexibility to sort of get a snapshot and look within the intestine in a very distinctive method after which optimize to enhance somebody’s well being going ahead.
And in addition, such as you stated, the physique’s pure state is well being. It’s not typically that we have to do something drastic. We have to get out of our personal method and simply take away the issues which can be protecting the physique from being wholesome or perhaps generally give it little further vitamins to assist get there. Speak a bit of bit in regards to the science of Viome and what we’re testing as a result of this know-how didn’t even exist a pair a long time in the past, and now we’ve got such superb knowledge from this.
Naveen: Properly, it’s very fascinating is this concept of, you recognize…for those who return and take a look at couple of a long time in the past, it was really the micro organism and all these organisms had been thought of as an enemy of the human physique. That’s the minute you see them, your job is to kill them as shortly as doable as a result of they’ll’t presumably be there for our good, proper. And as we began to study extra in regards to the human physique, we realized that the majority of those organisms are literally commensal. They’re purported to be there and so they in actual fact…after we feed them issues like, you recognize…in olden days, after we had been dwelling within the savannas of Africa, we’ll pull out a leaf or we’ll pull out the foundation and eat it. That’s stuffed with fiber. These fibers are literally what our intestine microbes eat, and people intestine microbes, by consuming these fibers, really flip them into brief chain fatty acids. Issues like butyric, issues like acetate, these had been all of the vitamins that our physique wanted.
In reality, for those who begin to consider it, 90% of all of the serotonin is definitely produced in our intestine, not in our mind. So, for those who actually take into consideration all of the issues which can be being finished within the intestine and the way what occurs within the intestine doesn’t merely keep within the intestine, it really impacts the entire physique together with our mind to coming again to it, Katie, that you just identified. What occurs in our intestine impacts our temper. So, whether or not it’s a despair or nervousness or, you recognize, you possibly can name them any names you need, you recognize, a lot of these items together with autism is now related straight into the intestine microbiome. In reality, they’ve finished now the analysis the place they did merely a microbial transplant referred to as a fecal transplant and so they had been capable of in actual fact present that children with autism, their autistic signs went down by 50% even after two years simply by merely doing the microbial transplant. They had been capable of present whenever you took an individual that has a despair a microbial transplant or nervousness, it may be transferred just by transferring the microbiome into one other species. They usually’ve finished them in mice and so they’ve finished that in actual fact in people, and clearly, it was finished by mistake however that’s really the way it occurred.
In reality, what’s actually fascinating is dependancy. They usually’ve proven the identical factor. They took…there have been 17 folks on the analysis that had been utterly hooked on alcohol. And people folks, they gave them a fecal transplant from individuals who really had no dependancy. And these folks’s dependancy went away. Now think about that, that our intestine microbiome are controlling our mind when it comes to what to do. That’s what the dependancy is, proper. And I believe that’s actually phenomenal.
And now what we’re studying is each kind of most cancers…in actual fact what they’ve now checked out is each single strong tumor has microbes inside that tumor. Take into consideration {that a} second, the microbes are contained in the tumor. And what we discovered most fascinating was there’s microbial peptides being displayed on the floor of the tumor. Now, why would a tumor that’s an organism eager to survive would ever show a microbial peptide except it’s there to idiot our immune system into pondering that is self and protects the tumor towards the immune system attacking, proper?
Now, think about what…one other factor that’s most fascinating I discovered was whenever you do immunotherapy, it really works about one-third of the time. And the folks the place the immunotherapy doesn’t work, within the 70% of the those that immunotherapy didn’t work, they merely had been capable of do a change of their intestine microbiome and the identical immunotherapy began working. So, our intestine microbiome will not be solely there to maintain us wholesome from all of the illnesses at this time we name the totally different names. Coronary heart illnesses, it’s coming from our intestine microbes really producing issues like trimethylamine or TMA. TMA will get absorbed within the blood and our liver converts them into TMAO, trimethylamine oxide. In reality, we will now take a look at issues like LDL manufacturing which is a nasty ldl cholesterol manufacturing and see how microbial actions and microbial metabolites really change the LDL manufacturing. You’re in a position to take a look at how…what’s taking place in your intestine, how are we altering the inflammatory markers in our host. So, we’re capable of measure the intestine exercise and the human host exercise, all their cytokines. So, we’re each interleukins, we’re the entire inflammatory markers to see how they’re altering with the intestine microbial exercise.
And so, anyway, the purpose I’m making an attempt to make is that you just talked about one thing about these micro organism, and I simply need folks to know the microorganisms usually are not simply micro organism. They’re predominantly micro organism however in addition they include yeast, viruses and even the RNA viruses or fungus or mildew. All of these items are literally the entire ecosystem and the largest half in actual fact for those who observed virtually 10 to 1 if no more is definitely phages. And phages are the viruses that infect the micro organism. And for those who take a look at any nature whether or not you’re trying within the swamp otherwise you’re trying on the intestine microbiome, in actual fact there are 10 instances extra phages than the micro organism alone. And meaning these viruses that infect micro organism are modifying the bacterial…the organism, the features of those micro organism that in actual fact adjustments how these micro organism behave when it comes to what features they’re performing.
So once more, what’s actually fascinating is by what organisms are there, won’t ever inform you what’s going on in your physique. In reality, their features are what makes the distinction. Which means what they’re producing can…is basically the one factor that issues what these intestine microbes are producing, not who they’re. And I believe, Katie, you most likely know that a variety of the folks like Akkermansia muciniphila. Among the firms are promoting them as a probiotic with out realizing that Akkermansia may be good for some folks and actually it’s the primary purpose for inflicting a number of sclerosis, and it has additionally been straight linked to Alzheimer’s, proper. So now give it some thought. The identical organism can do one thing good for one particular person and may do one thing actually unhealthy in one other particular person. So, taking one thing blindly, taking any complement, any probiotic, any prebiotic blindly is definitely not good for you as a result of your physique is totally totally different than different particular person’s physique. The identical organism or similar probiotic may be good for somebody and might be dangerous for one more particular person. And that’s the largest studying we’ve got had within the final six years.
Katie: Yeah, I really like that you just introduced up the fecal microbiota switch as nicely. I’ve seen among the science on this and… you recognize, caveat, this isn’t one thing to try at residence nevertheless it’s fairly superb what they’re carrying out in labs with some actually focused and really particular methods of doing that. And I really feel like in a way, that is additionally one thing you possibly can accomplish with out having to go to that excessive if you recognize what you’re working with. And for the final two years, I’ve been saying, you recognize, early on in well being and wellness, I might discover out info, learn research and be so excited and write about it, and I’ve realized increasingly during the last 15 years all the pieces is so customized and so individualized. And so now when folks ask me like, “What precisely did you do to reverse your Hashimoto’s?” I say, “, I can inform you what I did nevertheless it’s not gonna work the identical for you. It may be an concept with the place to begin nevertheless it’s not gonna be your blueprint. Every of our blueprints is gonna be very, very totally different.”
Which is why I really like now increasingly entry to those at-home testing whether or not it’s issues like Viome, even now blood testing accessible at residence, genetic testing simply so we will have extra info and entry. And I’ve stated so many instances on right here we’re every our personal major healthcare supplier. On the finish of the day, it’s nice to work with medical doctors however we’re every our personal major healthcare supplier. And I really feel like having instruments in our pocket that allow us be simpler at that may actually, actually make a distinction. So, let’s discuss a bit of bit extra in regards to the personalization side of this as a result of I additionally am curious…you recognize, I do know you stated all the pieces is so totally different. What’s good for one particular person could be not for one more. Are there any issues which can be sort of universally unhealthy that you just’re discovering in Viome? Like, I might put perhaps processed vegetable oils on the don’t cross listing, however I’m curious what you’re seeing within the knowledge.
Naveen: Yeah. So to start with, it’s actually fascinating. I believe you phrased it accurately. There isn’t any such factor as common wholesome meals. And meaning there isn’t a such factor that’s good for everybody. Which means the identical meals may be good for you or unhealthy for somebody. Nevertheless, there are some common unhealthy issues which you could know. So, there isn’t a common wholesome factor however there are universally unhealthy issues. Sugar is a type of unhealthy issues. There isn’t any one who says, “The sugar is nice for me, proper.” In order that’s really having a fried, you recognize, fried meals. So, all fried stuff, it’s simply unhealthy for everybody. Consuming a variety of sugar, it’s simply unhealthy for everybody. Nevertheless, what we discover most fascinating is that analyzing the human physique and analyzing based mostly on what’s going on and what’s dynamically altering in your physique…and I believe a variety of the people who find themselves listening to it, I need folks to grasp the distinction between a DNA which is static. So when folks do their DNA take a look at, it tells you what’s inherently there in your physique. It doesn’t inform you what is definitely happening in your physique. Which means…if, Katie, you enable me, I’m gonna clarify the DNA as a result of I believe to me lots of people get very confused about what DNA is.
So, each a part of our physique is equivalent DNA. Which means you take a look at my hair, you take a look at my eyes, you take a look at my tooth, you take a look at my nails, you take a look at my finger, it’s precisely the identical DNA. Then why is it we don’t have the eyes rising on my fingers and the nails rising on my head? Similar DNA. And the reply is there’s…when some genes are overexpressed, some genes are underneath expressed, the identical DNA can grow to be eye, similar DNA can grow to be nail, similar DNA can grow to be pores and skin, similar DNA can grow to be coronary heart cells or neurons or issues like that, proper. So, level is DNA is like an alphabet and the story you might be writing is definitely what’s being expressed. It’s referred to as RNA. So, RNA tells you the story that’s being written for you proper now and DNA tells you each doable factor that may occur. And that’s one factor.
So, what we do at Viome, Katie, is we take a look at your gene expression and what gene expression tells us is what story your intestine microbes are writing. What story your human host is writing. And now I’m gonna come again and inform you…some information to share with you in the direction of the top. As soon as we perceive all that’s happening, we’re capable of then inform you, “Hey, don’t eat broccoli or cabbage as a result of your sulfide manufacturing in your intestine is simply too excessive and the sulfide want sulfates to provide sulfide and the broccoli and cabbage are very excessive in sulfate so it’s best to reduce it down, proper.”
We are able to inform you that…lots of people will inform you go take vitamin B3. However vitamin B3’s really not good for you when you’ve gotten excessive uric acid manufacturing. So don’t take vitamin B3 you probably have excessive uric acid manufacturing. Equally, everybody will inform you, “Hey, take curcumin and turmeric. It’s actually good anti-inflammatory.” It’s. Nevertheless, when your bile acid manufacturing may be very excessive, you don’t need to take curcumin as a result of it’s going to transform into bile salt that’s gonna trigger extra irritation. Lots of people suppose in some way taking NAD or NR, and NMN which is precursor to NAD is definitely enhance your longevity. It’s true for some folks it might try this, however for others it really will hurt you when you’ve gotten excessive mobile senescence, or when you’ve gotten excessive inflammatory exercise. You don’t need to be taking extra NAD as a result of that’s gonna enhance the mitochondrial biogenesis that’s going to extend extra free radicals, gonna enhance excessive mobile senescence, proper.
So, the thought actually is that it’s a must to study what is going on earlier than you deal with your physique like a black field. And I believe you’ve stated it proper, that we’re simply…we’re the CEO of our personal well being. We’re those who have to know what is going on in our physique as a result of our major care physician…I don’t find out about you, Katie. Once I go to my major care physician, by the point I begin talking, he’s already writing the prescription. I imply, actually, the phrase he says… “Oh, did you say coughing? Right here it’s. Did you say this? Give me the in poor health, I’ll provide the tablet.” And that’s all they’re merely doing. They don’t have to…they don’t care to grasp what’s inflicting that to occur in my physique. Like, you had Hashimoto, or for those who had any kind of an autoimmune illness, the very first thing they inform you is simply take the immune suppression medication and suppress the symptom. Not fear about what’s inflicting it, and that could be a elementary drawback that our healthcare system has is that our medical industrial complicated, everybody makes cash after we are sick and nobody makes cash after we are wholesome. And so, we determined to vary that. In my world of the long run, Katie, we consider that…I believe similar to you simply stated, the way forward for healthcare goes to be delivered at residence, not on the hospitals.
And the medicines of the long run are gonna come from a farm, not a pharmacy. And that’s going to be the largest change you’ll begin to see us taking management of our personal well being. And I believe COVID has been one of many…I might say for those who look again at COVID 10 years from now, it will likely be the largest inflection level that occurred in humanity’s notion of that we as people have management our personal actions and our actions have well being penalties.
Katie: Completely. I believe so many good silver linings and educating moments in COVID and folks spent extra time at residence and with their households cooking dinner at residence. There have been a variety of nice outcomes, as exhausting because it was for many individuals. I believe we will deal with these positives. And I really like your clarification of DNA and the way it goes past simply your genetics. It’s about how they’re expressed and the way that’s managed within the intestine. And I’d like to go a bit of bit deeper about Viome as a result of I do know I talked to you years in the past about this and also you guys have made some massive advances since then. So, discuss sort of the snapshot of what Viome is testing after which how persons are making adjustments based mostly on that and what they’re seeing.
Naveen: Sure. So clearly, Katie, a few years in the past we did a intestine intelligence chart that merely measured your intestine well being. After which we realized that that was actually good nevertheless it didn’t inform us how these intestine adjustments had been impacting us and the human physique. And so, we now launched…about two years in the past throughout COVID really, we launched our well being intelligence take a look at that measures your blood and it measures your stool, and by doing the finger prick blood, so that you don’t must go to a lab. It’s a easy finger prick blood, couple of drops of your blood. And your starch of your stool. We’re capable of now take a look at each your intestine well being and your human host and capable of now inform you what’s your organic age. And that tells you not solely, you recognize, how nicely or how poorly your physique is getting older in comparison with your chronological age.
So, to present you an concept, I’m now gonna be 63 in September and my organic age is all the way down to 50. And that tells you that actually that my physique is performing on the stage after I was 50. And I really feel it. I run up the steps two stairs at a time and I’ve extra power than in actual fact I had after I was 50. And that merely tells you what your organic age is. Then we provide you with immune well being. Which means how nicely are you protected towards for those who had been to catch flu or chilly or any kind of pathogen, how nicely your physique is ready to shield itself? And that’s your immune well being. Your mobile well being. That tells you the way nicely your cells are capable of bear the issues which can be happening within the human physique. Mitochondrial well being, that’s your power manufacturing unit. How nicely the mitochondrial well being is performing as a result of if it’s not, you get mind fog, you’re feeling fatigued, you’re feeling drained. We provide you with clearly your intestine well being.
And now that is one thing new that we’re gonna be launching in June and we’re launching a brand new product referred to as full physique intelligence. And for the primary time, we’re gonna be analyzing all the best way from prime of your tube, your saliva, your stool and blood, all three on the similar time. And by that, we’re additionally gonna have the ability to present you some extra insights equivalent to your coronary heart and metabolic well being. We’re gonna be supplying you with your mind and cognitive well being. We’re gonna have the ability to present you your oral well being equivalent to your gum well being, your tooth well being and all of the gum, you recognize…leaky gum as an alternative of simply leaky intestine. We’ll have the ability to present you the way nicely your boundaries of your gums are performing in order that microbes usually are not going into your blood.
And different factor we do now which we didn’t do till a few yr in the past is whenever you do a take a look at, not solely you get your deep perception what’s taking place in your physique and never simply inform you listed below are the meals which can be good for you and right here is why. Listed here are the meals it’s best to keep away from and why. We used to inform you listed below are the dietary supplements it’s best to take. Now we transcend that, Katie. We’re capable of inform you you solely want 22 milligram of berberine day-after-day. You want 17 milligram of elderberry day-after-day. You want 79 milligram amylase day-after-day. And we undergo each vitamin, minerals, herbs, meals extracts, digestive enzymes, amino acids, probiotics, prebiotics, and we actually make these for you on demand.
There isn’t any premade stuff. Consider it like a compounding pharmacy. There are robotics compounding pharmacy. It says, these capsules are being made for Katie. Go to bin quantity 17, get 17 milligram of elderberry. Go to bin quantity 29, get 27 milligram of berberine. And we actually take all of the strawberry extract right here, put this factor right here. And by the best way, as soon as we get the powder, we make the capsules and ship them off to you each month. And as your physique adjustments, we alter your dietary supplements on the similar time. So, each time you retest, we are saying, “Oh, you don’t want amylase anymore. What you really want is butyrate now,” proper. And we actually are capable of modify your…as your physique is altering, we adapt the diet that your physique wants. And people are the brand new issues that I’m tremendous enthusiastic about.
Different issues that I’m actually, actually enthusiastic about…and we’ve got not talked to anybody but about it. We’re gonna be launching in June additionally our most cancers detect. And that is gonna…first time as a client you’ll have the ability to spit in a tube and with 95% specificity and 90% sensitivity, we’ll have the ability to inform you you probably have any oral most cancers or throat most cancers. After which we’ll have the ability to really join you with a health care provider to have the ability to do one thing about it. So, if you’re above…over 50 years previous or have any historical past of smoking, vaping, chewing tobacco, you’ll have the ability to really at residence do a take a look at and really know that you just’re not at a threat of growing a most cancers proper now. Otherwise you’re growing a most cancers proper now.
Katie: Yeah. That is so leading edge and I believe simply to spotlight what you stated, that is actually fascinating information of principally machine studying and AI and this adaptive know-how. And since you’ve now examined 1000’s and 1000’s, most likely a whole bunch of 1000’s of individuals, then the algorithm has entry to all this info so it could actually proceed to get increasingly specialised and direct with the suggestions and study your personal physique over time. So, you’re getting this type of ongoing, correct image which I believe is so fascinating.
Naveen: Yeah. So, Katie, we’ve got analyzed over 350,000 samples already. And that has given us this…you recognize, the a part of being the…a part of that Viome ecosystem is each single one who joins profit from the opposite 350,000 samples that we’ve got analyzed and so they contribute to the ecosystem, and our AI and machine studying is continually getting higher. And for each single one who joins profit themselves and advantages the humanity on the similar time as a result of now the extra we study, the higher suggestions we will make for everybody. So, earlier than we simply solely may take a look at your stool. Now we take a look at stool plus blood. Now it’s stool plus blood plus saliva. And we’re gonna launch…the subsequent factor might be with urine. After which we’re gonna begin to take a look at different biomarkers in your physique. So, our suggestions get increasingly exact as we study increasingly in regards to the human physique. And our actual hope is, you recognize, in my lifetime we’ll have the ability to perceive what causes the onset of a persistent illness and what causes them to progress and to have the ability to forestall them from taking place within the first place, to diagnose them early once they really do occur, and to provide you with a treatment for these illnesses. Not merely handle them however to treatment them as soon as for all for every particular person. And that’s going to be the last word purpose of our life.
Katie: And I really like that you just introduced up the interplay of all of the totally different microbiomes throughout the physique as nicely and the way you’re all of those, as a result of a few of my early analysis was in oral well being and studying as an example that strep mutants and the micro organism that trigger gingivitis don’t each exist on the similar time. And it is because we’ve got an oral microbiome. And if it will get out of stability in a single path or the opposite, you’re gonna find yourself with these issues. However the reply will not be sterilizing your mouth and killing all micro organism similar to we wouldn’t need to within the intestine. It’s getting a wholesome oral microbiome that has that ecosystem that it wants. Similar factor with the intestine. And such as you stated, you’re these all through the entire physique. I do know your daughter’s additionally performing some fascinating analysis with the vaginal microbiome and I’m excited to speak together with her about that.
However I believe, like we talked about to start with, since our physique is extra bacterial than human, the extra we perceive about these interactions, the extra sort of intricate knowledge we will get to make enhancements over time and naturally there can be a most cancers connection right here. , I’ve heard it stated that most cancers is a metabolic illness in some half. And it is a method of…as a result of even inside a person, for those who’re a metabolic illness, you’re , “Okay, we have to get blood sugar in test. We have to get blood strain in test. We have to get weight problems measures in test.” However the best way to try this’s gonna be totally different for each single particular person.
Naveen: I believe it’s a metabolic and inflammatory illness. So, I imply, it’s induced…persistent irritation is a root reason for persistent illnesses. Nevertheless, what causes the irritation in our physique is totally different for every particular person. So despite the fact that it’s the irritation which may be on the root trigger however the underlying causes for that irritation are very, very totally different. And as you talked about, our daughter is, you recognize…has this firm referred to as Evvy, E-V-V-Y, which appears to be like on the vaginal microbiome. And to me, what she’s doing is so phenomenal and particularly your viewers, each single girl ought to try this as a result of that’s actually…goes to be…you recognize, numerous girls endure by lots of the illnesses that we as males would by no means perceive. And that to some extent is, you recognize, largely reproductive organ and lots of the instances the later analysis exhibits that vaginal microbiome is concerned in preterm delivery, within the well being of the child and all of the issues that you just talked about because the child goes by the delivery canal. All of the issues that come out in actual fact are contributory from the vaginal microbiome. So, my excessive advice…once more, I’m biased. I believe each girl ought to be doing the Evvy take a look at, proper.
Now, coming again to the belongings you talked about that, you recognize, human well being is complicated however as soon as we perceive biochemical stage what’s going on, that’s the rationale as an alternative of organisms and as an alternative of DNA, we targeted on the gene expression or RNA. We targeted on what microbes are producing. Wanting on the complete physique. And I believe, Katie, I wanna level out that the merchandise that you just construct for oral well being are among the greatest merchandise as a result of, to me, what’s the largest gamechanger is folks thought the organisms had been your enemy. So, they’ve this Listerine. Kills 99% of all of the micro organism in your mouth. For heaven’s sake, don’t try this. Once you kill the ecosystem in your mouth, it really destroys the entire digestive tract. And I wanna simply emphasize, you recognize, to folks when our moms advised us to chew our meals, she didn’t ask us to chew the meals as a result of they thought the meals was too massive to go down our esophagus, proper. It was really was whenever you chew your meals, you’re permitting the oral microbiome in your saliva to really predigest the meals, and by predigesting the meals…along with predigesting, it additionally sends the sign to the intestine and to the physique about what’s coming down. So, when it tastes candy, it begins to launch the sign for pancreas to launch the insulin, as a result of it is aware of the candy stuff is coming down.
So, the primary factor is that we have to enable the oral microbiome to predigest the feed so your small gut can now take in the vitamins which can be already predigested. So, if you end up…so two issues it’s essential to take into consideration right here. And one is if you end up careworn and you might be consuming your meals, it doesn’t get correctly digested and right here is why. When you’re careworn, you might be in a struggle or flight response. And the primary factor that occurs whenever you’re in struggle or flight response is your digestive system shuts down. Bear in mind why it was designed. Once you’re operating away from a tiger, at the moment, the physique knew there isn’t a level worrying about digesting your meals as a result of both you’re gonna be lunch for another person otherwise you’re going to outlive. And for those who grew to become lunch for another person, it didn’t matter. And for those who survive, guess what? The stress went down and also you moved from sympathetic mode to parasympathetic mode and you may digest your meals.
Once you come from work and you might be careworn, what can we inform folks? Earlier than you eat, do the gratitude. Why is that? It’s since you need to deliver your physique from sympathetic mode into parasympathetic mode. Eliminate struggle or flight response. By taking the deep breath, by doing the gratitude, what you might be doing is definitely permitting your physique to have the ability to be able to digest the meals. Then whenever you chew your meals, you’re permitting your saliva and oral microbiome to really predigest your meals. And these are easy strategies we discovered within the historic tradition however we now know scientifically why did they are saying that, proper. We inform…like, Katie, you might not know that my mother and pa and our faith, they don’t eat after sundown. And I at all times surprise why would that be. And it seems as a result of it’s essential to have three or 4 hours of break after you eat meals earlier than you fall asleep. So, they made that as a faith don’t eat after sundown so as a result of folks will get three, 4 hours of digestion. So, in actual fact telling that, you recognize…and that to me was actually the factor that we discovered as a part of our tradition. Truly, seems we’re very scientific.
And I wanna come again to the oral merchandise. I believe folks have to be actually fascinated with oral microbiome well being and utilizing the precise oral toothpaste, oral issues that…you recognize, probiotics. And the merchandise, among the merchandise that you’ve got, Katie, are designed to reinforce your oral well being and oral microbial actions or oral microbial ecosystem in your mouth. And I believe everybody who’s listening to it to begin listen as a result of that’s the primary. Your mouth really is the start of your digestive tract. It isn’t merely a gap to your digestive tract. It’s the path of the digestive tract the place the digestion occurs.
Katie: I completely agree. I believe very multifaceted however begin with the mouth is so necessary. And I really like a few the belongings you simply talked about about why we don’t digest meals if we’re careworn and we all know, after all, that Individuals reside in a persistent state of stress typically. And one factor I’ve grow to be keen on…you recognize, there’s a purpose many cultures additionally pray or meditate proper earlier than consuming, which additionally helps the physique get into parasympathetic or you possibly can merely do respiration workouts. Do some field respiration to calm your nervous system. I really like that your loved ones naturally from a spiritual perspective stopped consuming at sundown. I’ve discovered in my very own life that I do nice after I time restricted eat and for a very long time I might wait and never eat until midday after which eat later within the day. And I observed after I shifted that to consuming and stopping by sundown, I really feel so a lot better and it goes to that time you talked about about letting your physique end digesting earlier than you sleep in order that whenever you’re sleeping, you may be therapeutic and your physique can get into autophagy and you’ll allocate assets to all of the pure processes the physique has inbuilt to maintain us wholesome.
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And I additionally wanna piggyback on what you stated about the identical purpose we don’t wanna kill our oral microbiome is similar purpose we don’t wanna kill our intestine micro organism as nicely however I nonetheless see folks sort of hopping on the bandwagon of those actually harsh cleanses or after all folks generally take antibiotics for causes whether or not they should or not. And people can each have a reasonably harsh affect on the intestine. And so, I’d love to speak about it. Perhaps if somebody is aware of they’ve been on antibiotics earlier than or they know they’ve a intestine challenge associated to actually sort of killing a few of these good micro organism. Clearly, Viome helps with this however sort of, like, what may be finished? How can we assist repair it?
Naveen: So, very first thing is, you recognize, earlier than you go begin taking a variety of issues is to grasp, what’s the state of your intestine micro organism? So do a Viome take a look at, perceive the place it stands. And you then begin to take a look at what you…you recognize, we inform you what are the meals it’s best to eat. And once more, taking a variety of the fermented meals particularly whenever you’re making an attempt to repopulate or rebootilate your intestine microbiome, actually the issues ought to be diversification. So as an alternative of simply taking one kind of probiotics, you ought to be taking kombucha, the kimchi, the…you recognize, all of the fermented meals you possibly can presumably get your arms on. So, whether or not it’s a yogurt or, you recognize, at the least oat milk yogurt for those who can. I imply, I’m an enormous fan that I believe dairy…in actual fact for lots of the folks, dairy is the massive drawback. Now I’m not saying it’s for everybody however a variety of the folks, dairy might be an enormous drawback. And the mammalian merchandise really might be an enormous drawback for some folks and never for others.
So, I’m not the one who is preaching veganism right here in any respect. What I’m saying is know what is nice for you. There are lots of people who can eat crimson meat for all of their life and reside to be 100, and the rationale for that’s crimson meat incorporates clearly as you all know, choline and carnitine that may get transformed by our intestine microbiome into issues like TMA. And I discussed TMA is the one which will get absorbed within the blood, causes the TMAO which causes the center illness. So, it’s not the crimson meat that causes the center illness. It’s the byproduct of how the crimson meat is digested in some those that produce TMA. So, in case your TMA manufacturing is low, it’s best to eat crimson meat if you wish to as a result of it’s not gonna hurt you. And that’s actually the purpose is to grasp, don’t merely ban meals and complete class of meals.
One other factor that we discovered…we revealed a paper having analyzed over 100,000 folks at the moment on getting older. And what we discovered, Katie, that you could be discover actually fascinating is individuals who had been on these fad diets like, you recognize, keto eating regimen or paleo eating regimen had been the worst offender of their organic age. The individuals who had been on keto eating regimen in actual fact had been three to 5 years older than their chronological age and the identical is true for paleo eating regimen. It seems that people who find themselves on balanced eating regimen, meaning they had been consuming their carbs however not loads however they had been consuming their regular carbs, they had been consuming their protein, they had been consuming their fats and so they had been consuming the protein, they had been rather more balanced, had been really higher off biologically than reducing out the entire nutrient group utterly.
Katie: That is sensible, that we want the range. And I’ve discovered increasingly as nicely that I believe the simplistic model all of us discovered, hopefully discovered in class was about simply sort of energy in, energy out. And I’ve heard it stated, you recognize, our physique’s not a checking account. It’s a chemistry lab. And so, I now attempt to eat for maximal micronutrient and nutrient density in meals, not simply hitting or not hitting goal calorie ratios as a result of it’s a lot extra numerous and necessary than that.
And what’s subsequent for Viome? I’m curious as a result of I do know you’re continually doing analysis right here, and such as you stated, your purpose is to deal with persistent illness in its entirety. So, what’s within the pipeline for you guys?
Naveen: Truly, I discussed that subsequent take a look at we’re launching in June is a full physique intelligence. We’re launching a most cancers detect take a look at. And we’re making our dietary supplements and probiotics increasingly exact for each particular person since we make it for every particular person. We’re, you recognize, making an attempt to do extra checks now and our purpose is to launch within the subsequent six months one other take a look at which is gonna be extra, like, a proteomics take a look at as a result of the issues we can’t see within the blood as a result of they’re produced some place else. So, can we measure issues, you recognize, the proteins for a Hashimoto illness? Can we measure issues like lipopolysaccharide binding protein that may predict you probably have a leaky intestine by LBP, by CRP which really is finished within the liver? So, we’re going to have the ability to really measure extra issues along with simply those that we’re measuring, and the extra info we will study, the higher suggestions we make. So, our hope is to proceed to launch these checks that give us higher and higher insights and meaning we will make increasingly exact advice for every particular person.
Final purpose actually is to grasp…as you say, the human physique is a chemistry lab. We’ve principally biochemical reactors in our physique. Your physique is a biochemical reactor. And that’s the factor folks want to grasp that the gene expression tells you what biochemistry is occurring within the physique. And that’s a purpose…and actually, Viome is the one firm that does take a look at the gene expression as a result of there isn’t a different firm that has this know-how. And I believe individuals who have listened to your earlier podcast, we talked about, this explicit know-how got here out of Los Alamos Nationwide Lab the place that they had the laboratory for biodefense challenge. And that’s the rationale nobody else can do it as a result of it took 10 years and multibillion {dollars}’ value of assets to develop this know-how. Sadly, we had been very lucky to have the ability to get the license to have the ability to use this know-how to assist the humanity get higher. And if our mission was merely to earn money, we’d not have been capable of license this know-how, proper.
So, the actual fact at this time we’re merely targeted on making each single particular person be higher. , our mission on day one was what if we may perceive the human biology at a molecular stage so we will forestall, diagnose early and treatment these persistent illnesses together with most cancers and getting older? And I believe a variety of the individuals who have heard you and I discuss prior to now, you recognize that I misplaced my dad to most cancers and that was one of many largest motivator for me as a result of if I had began this firm half a decade earlier than I did, I may have doubtlessly saved my dad. And, you recognize, having watched him undergo that ache or struggling by most cancers I spotted that despite the fact that I couldn’t save him, I may dedicate my life to saving everybody else. And that might be my method of letting him know that, you recognize, I’m so happy with what he…how he raised us as a toddler and giving us all the pieces we’ve got so we’re capable of save everybody else’s family members whether or not it’s from coronary heart illness or diabetes or despair, nervousness or most cancers.
And my hope actually is that in our lifetime we are going to completely eradicate most cancers from the human physique. And if I had been to make a prediction at this time, I’ll inform you inside a decade I believe we are going to do away with most cancers from the human physique.
Katie: That’s an enormous declare and I hope we’re on monitor for that as nicely. I’ve misplaced two prolonged members of the family within the final couple of months alone to most cancers in addition to a few of my grandparents. And it’s no secret that these are all nonetheless very a lot on the rise proper now and I’m certain the persistent stress of the final couple of years will not be serving to that drawback. So, I’m grateful that there are assets such as you, and I’ve finished Viome. I’m doing an up to date one proper now so I can report again with my outcomes on that. However I additionally am gonna be sure that…I do know you’ve supplied a reduction code for the Viome testing. In order that hyperlink might be within the present notes for you guys listening at wellnessmama.fm. You’ll find the low cost code and the hyperlink on to it there. And to ensure I respect your time, there’s a pair final questions I might like to ask you. The primary being if there’s a guide or plenty of books which have profoundly influenced your life. And if that’s the case, what they’re and why?
Naveen: Yeah, so the guide that basically influenced me…there’s a guide by Clayton Christensen, you recognize. I really like the person and I noticed him earlier than he died. The guide he wrote, “How Will You Measure Your Life?” And to me it was such a profound guide which tells you that it’s a must to be 100% trustworthy. You can’t be 99% trustworthy as a result of as soon as you are taking a step down of this honesty, it’s a slippery slope and there’s no stopping it. When you make an exception to one thing, there’s simply no going again however there’ll at all times be another excuse to make an exception. And so, it’s a must to focus your self to by no means, ever compromise in your rules that you just stand for. And that was simply completely a wonderful guide I learn.
, the guide that additionally…I imply, clearly I wrote a guide referred to as “Moonshots” that’s actually about making a mindset of abundance moderately than a mindset of shortage. And the elemental perception that I’ve is that there’s nothing that people usually are not able to doing if we really get our mindset to consider we will. So, any time when somebody says, “I can or I can’t,” it’s true as a result of it’s as much as them to determine whether or not they can or they’ll’t. That when you consider one thing is unattainable, it turns into unattainable for you and nobody else. And so, you might be utterly in management. The one factor you possibly can’t do is what you possibly can’t think about. All the pieces else is feasible.
Katie: I really like that. I do know you and I each elevate our youngsters with that mindset and yours are older and doing superb issues out on the planet already and mine are to start with phases of that. And lastly, what parting recommendation would you want to depart with the viewers at this time? May very well be associated to one thing we’ve talked about or completely unrelated.
Naveen: I might say dream so massive that folks suppose you’re loopy. Which means by no means let somebody inform you which you could’t do it. Fall in love with your self as a result of the day you fall in love with your self is the day the world will fall in love with you. Loving your self will not be about being self-conceited. Loving your self is about not on the lookout for another person’s approval to do the issues that imply loads to you. Comply with your coronary heart, comply with your intestine, take heed to your intestine and comply with what it tells you. Discover a objective in life. When you discover a objective in life, you’ll by no means ever suppose it’s work. I stand up day-after-day at 4 a.m., and that’s my recommendation to everybody. Everytime you stand up within the morning, for those who’re not leaping out of the mattress, it’s best to stop what you might be doing as a result of that’s not your calling, as a result of whenever you discover your calling, you’ll not be mendacity down within the mattress. You soar out of the mattress with pleasure wanting to unravel that drawback.
And, Katie, I simply need to reiterate, I met your children and I do know I bear in mind the oldest one and I gave him the Moon rock at the moment. I’m telling you your children are going to really transfer this humanity ahead. You’re elevating these youngsters with the mindset that all the pieces they need to do, they’ll. And each mom who’s listening to it simply ought to know that parenting is definitely very counterintuitive. And, Katie, you and I’ve talked about it a variety of instances. Like, after we elevate our kids, we inform them, “Our love for you is unconditional however our approval will not be.” And what meaning is just is that we’ll at all times love you, we’ll at all times be there for you, however I’m not gonna inform you I’m happy with you except you do issues that make us happy with you. And that’s actually the factor about telling the youngsters that their success won’t ever be measured by how a lot cash they’ve within the financial institution. It will likely be measured by what number of lives they enhance. And the humility is an indication of success as a result of for those who nonetheless have iota of conceitedness left in you, meaning you’re nonetheless making an attempt to show one thing to your self or another person. And humility tells you not have to try this, proper. And that could be a true signal of success. And all I can say is I’m so happy with each considered one of your youngsters, Katie. And I can’t watch for them to develop up and really do issues that may make our kids’s and grandchildren’s life higher.
Katie: Oh, thanks a lot for saying that. Individuals who don’t know, you and I first met and actually bonded over really parenting earlier than we ever talked about well being. And we share that similarity. I inform my children day-after-day, “I really like you unconditionally and there’s nothing you ever must do to earn my love and there’s nothing you may ever do that may take away from my love.” However you’re proper. Additionally, I need that, like, their satisfaction to return from within, like…and I inform them typically, “You will need to really feel actually happy with how exhausting you labored and you need to…” As a result of I need them to have that inside them and that self-love.
And this is the reason I’m so grateful each single day that I get to speak to our viewers that’s listening at this time of mothers, as a result of I believe mothers have such a tremendous distinctive potential to actually shift the way forward for humanity by how we dad or mum our youngsters and by serving to kind these future leaders. And for individuals who aren’t already acquainted with you, I might encourage you to take heed to our previous interview since you inform extra of your story in that one and also you very a lot stroll the stroll of this, of getting constructed all these superb issues after which now serving to your children on their life journeys and your spouse in her personal proper is unimaginable as nicely. So very grateful in your complete household and for all that every one of you might be doing on the planet and in your time at this time. I understand how busy you might be and I’m so grateful you took the time to be right here.
Naveen: Oh, Katie, it’s at all times an honor and a pleasure to be talking with you, and I’m trying ahead to our subsequent dialog.
Katie: And thanks, as at all times, to all of you for listening and sharing your most beneficial assets, your time, your power, and your consideration with us at this time. We’re each so grateful that you just did. And I hope that you’ll be a part of me once more on the subsequent episode of the “Wellness Mama” podcast.
If you happen to’re having fun with these interviews, would you please take two minutes to depart a score or assessment on iTunes for me? Doing this helps extra folks to seek out the podcast, which suggests much more mothers and households may gain advantage from the knowledge. I actually respect your time, and thanks as at all times for listening.
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